Causes and Determinants of Mortality in HIV-Infected Adults With Tuberculosis: An Analysis From the CAMELIA ANRS 1295-CIPRA KH001 Randomized Trial
نویسندگان
چکیده
منابع مشابه
Causes and determinants of mortality in HIV-infected adults with tuberculosis: an analysis from the CAMELIA ANRS 1295-CIPRA KH001 randomized trial.
BACKGROUND Shortening the interval between antituberculosis treatment onset and initiation of antiretroviral therapy (ART) reduces mortality in severely immunocompromised human immunodeficiency virus (HIV)-infected patients with tuberculosis. A better understanding of causes and determinants of death may lead to new strategies to further enhance survival. METHODS We assessed mortality rates, ...
متن کاملPlasma Concentrations, Efficacy and Safety of Efavirenz in HIV-Infected Adults Treated for Tuberculosis in Cambodia (ANRS 1295-CIPRA KH001 CAMELIA Trial)
OBJECTIVE To assess efavirenz plasma concentrations and their association with treatment efficacy and tolerance of efavirenz 600 mg daily in HIV-tuberculosis co-infected patients. METHODS HIV-infected adults with CD4+ T cell count ≤ 200/mm(3) received standard 6-month tuberculosis treatment and antiretroviral therapy including a daily-dose of 600 mg of efavirenz, irrespective of their body we...
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Methods (i) 138 HIV+/TB+ patients enrolled in the CAMELIA trial (ANRS 1295-CIPRA/KH001-DAIDS-ES ID10425) in Cambodia and 36 HIV+ patients with CD4 T cells < 200/mm included (ii) NK cells repertoire analysis by immuno-staining in whole blood and, (iii) NK cells degranulation activity and cytokine production by CD107a essay with and without stimulation. After starting of TB therapy in HIV+/TB+ pa...
متن کاملTreatment strategies for HIV-infected patients with tuberculosis: ongoing and planned clinical trials.
Currently, there are limited data to guide the management of highly active antiretroviral therapy (HAART) for human immunodeficiency virus type 1 (HIV-1)-infected patients with active tuberculosis (TB), the leading cause of death among individuals with acquired immunodeficiency syndrome (AIDS) in resource-limited areas. Four trials to take place in Southeast Asian, African, and South American c...
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ژورنال
عنوان ژورنال: Clinical Infectious Diseases
سال: 2014
ISSN: 1058-4838,1537-6591
DOI: 10.1093/cid/ciu283